Methadone Safety: Clinical Practice Guidelines from the American Pain .
• Methadone accounted for 1.7% of opioid prescriptions in 2009 and 9.0% of morphine equivalents in 2010. 1 • Methadone was associated with 31% of opioid- related deaths and 40% of single-drug deaths. 1 • For chronic non-cancer pain, methadone evaluated in a single, small, poor-quality trial of neuropathic pain. 2. 1 . MMWR 2012;61:493- 7. 2