Transcription

Basic and TranslationalCardiovascular Research TrainingProgramHandbook2021-2022

ContentsOverview of the UVA CVTG . 2Administrative Structure . 3Financial Support for CVTG Pre-doctoral Fellows . 5Financial Support for CVTG Post-doctoral Fellows . 7UVA CVTG Courses and Events . 10CVTG Attendance Policy . 13CVTG Reimbursement Procedures . 13Annual Progress Report Meetings . 14Appendices . 14Appendix A: List of CVTG Mentors by Focus Area . 15Appendix B: CVTG Program Annual Progress Report . 16Appendix C: Translational Clinical/Observation Experience Clinicians . 18Appendix D: CVTG Research in Progress Sessions Formats, Guidelines, and Suggestions . 19RIP Session Formats and Frequency . 19Suggestions for all session formats . 19Elevator Pitches . 20Hot Seat Sessions . 20RIP Research Presentation Guidelines . 20

Overview of the UVA CVTGMissionThe goal of our NIH Basic Cardiovascular Research Training Grant (CVTG) Program is to train individuals tobecome outstanding biomedical scientists who will pioneer major advances in our understanding of CV biologyand disease and develop novel therapeutic interventions through research.Program OverviewName of DirectorTenure as DirectorRobert M. Berne, Ph.D.1967-1986Brian R. Duling, Ph.D.1986-2012Gary K. Owens, Ph.D.2012-presentCardiovascular disease (CVD) is the leading worldwide cause of death, and alterations in the function ofvascular cells also play a key role in the pathogenesis of nearly all major human diseases including cancer,diabetes, and neurodegenerative disease. While there has been significant progress in our understanding ofCVD and related diseases in the last decade, there are still major deficiencies in our understanding of thesediseases and our ability to prevent or treat them effectively.We provide broad interdisciplinary training in basic cardiovascular biology and disease as well noncardiovascular diseases such as cancer and neurodegenerative diseases where cardiovascular dysfunctionplays a critical role. Trainees get exposure to all major scientific disciplines including cell and molecularbiology, immunology, biomedical engineering, neuroscience, biochemistry, pharmacology, and genetics/omicsjust to name a few. The central component of the program is the opportunity to do high impact original CVresearch with one or more of our 42 CVTG mentors. In addition, we provide numerous workshops, seminars,specialized courses, and other activities designed to optimize your ability to do truly outstanding research.Areas of research emphasis include studies of basic cardiovascular function (focus on smooth muscle,endothelium and leukocytes), as well as cardiovascular diseases (focus on atherosclerosis, hypertension, andstroke). Our faculty members and their trainees use state-of-the-art experimental approaches to addresssome of the most important problems in medical science. A major and continuing focus of our studies is todevelop novel drugs, devices, diagnostic methods, and therapeutic approaches to advance treatment ofcardiovascular diseases.The training program supports 8 pre-doctoral and 7 post-doctoral trainees. The first year of training forgraduate students is done in one of 7 Biomedical Sciences (BIMS) Graduate Programs after which the traineechooses a research mentor and a PhD Program for completing their training. These degree programs work inconcert with our CVTG to optimize and customize your PhD training program with the degree programproviding a general foundation of knowledge and skills, and the CVTG providing specialty training in CV biologyand disease.Post-doctoral fellow training is primarily under the direction of a research mentor. However, given thecomplexity of modern biomedical research, all trainees are urged to interact and collaborate with multiplelabs, and the training in your individual labs is augmented by the various training activities of the CVTG. Thetraining of both pre- and post-doctoral fellows includes the following: 1) a monthly cardiovascular researchin-progress presentation series (the RIP’s) which includes presentations by fellow trainees, “hot seat” sessions,2021-2022 UVA CVTG Handbook page 2

and elevator talks (3-5 minute summary presentations); 2) grant writing workshops and grant brewingsessions; 3) a CVRC/CVTG seminar series; 4) specialized advanced CV courses; 5) workshops and courses forprofessional advancement including time management, starting your own lab, interviewing for jobs, managingyour own lab, working in industry or the biotechnology field, doing translational research, etc. ; 6) an annualresearch retreat; and 7) attending and presenting your research at national/international meetings. Ourtraining program is strongly backed by the University of Virginia, School of Medicine, which has establishedthe Cardiovascular Research Center (CVRC) as a focus for coordinating cardiovascular research and trainingthroughout the University.Only citizens and permanent residents of the United States are eligible for training grant support, accordingto regulations set forth by the National Institutes of Health, the funding agency for this program.Administrative StructureUVA CVTG AdministrationG Owens, PhDMolecular and genetic mechanisms that control thestability of advanced atherosclerotic lesionsProgram Director, Executive Committee Chair; Professor ofMolecular Physiology and Biological PhysicsB Isakson, PhDIntercellular Communication in Normal and DiseaseState Vasculature.Associate Director for Curriculum, Executive Committee Vice Chair;Professor of Molecular Physiology and Biological PhysicsN Leitinger, PhDRole of Lipid Oxidation Products in Inflammationand Vascular Immunology in Atherosclerosis andDiabetesAssociate CVRC Director, Executive Committee Member;Professor of PharmacologyS Peirce-Cottler, PhDComputational Systems Biology, MicrovascularRemodeling, Stem CellsAssociate Director for Scientific Programs, Executive CommitteeMember; Professor of Biomedical EngineeringK Walsh, PhDThe Walsh Lab broadly examinesthe molecular events that drivecardiovascular cell growth,differentiation and cell deathAdvisory Committee; Professor of Research, Medicine, andCardiovascular MedicineC McNamara, MDAtherosclerosis, Obesity, DiabetesM Civelek, PhDIdentification of geneticmechanisms that lead to increasedsusceptibility to cardiovascular andmetabolic diseasesAdvisory Committee; Professor of Medicine, CardiovascularMedicineAdvisory Committee; Assistant Professor of Biomedical Engineering;Resident Faculty at the Center for Public Health GenomicsJ Saucerman, PhDRoles of Complex Signaling Networks Involved inthe Regulation of Cardiovascular Function andDiseaseAdvisory Committee; Associate Professor of Biomedical EngineeringK Hirschi, PhDControl of vascular development and angiogenesisAdvisory Committee; Professor of Cell BiologyA Somlyo, PhDSignaling Pathways that Regulate Contractility inSmooth Muscle TissuesAdvisory Committee; Professor of Molecular Physiology andBiological PhysicsJ Miano, PhDTranscriptional regulation of gene expression;pathobiology of SRF and myocardin; genome miningExternal Advisory Committee; Associate Director, AabCardiovascular Research Institute, University of RochesterLuisa Iruela-Arispe, PhDMolecular mechanisms that regulate angiogenesisduring development and in pathological conditionsExternal Advisory Committee; Stephen Walter Ranson Professor andChair, Department of Cell and Developmental Biology,Northwestern University Feinberg School of MedicineM Sturek, PhDCellular and molecular mechanisms for in vivocardiovascular phenomena.External Advisory Committee; Chairperson, Professor of Cellular &Integrative Physiology, Professor of Medicine, Indiana UniversityDr. Owens is involved with all aspects of the program, and reports directly to the Dean of the School ofMedicine, Dr. David Wilkes. However, to spread the considerable administrative responsibilities of the2021-2022 UVA CVTG Handbook page 3

Program, and to ensure a high level of programmatic oversight of training, we have created an ExecutiveCommittee consisting of Dr. Owens, the CVRC Associate Director Norbert Leitinger, and two Associate DirectorPositions with well-defined responsibilities. The Associate Director positions include: Curriculum andWorkshops (Dr. Isakson) and Scientific Programs and Student Advising (Dr. Peirce-Cottler). Drs. Owens,Isakson, and Leitinger plus the CVTG Associate Directors, plus 4-6 additional faculty members and the ProgramAdministrator form the CVTG Advisory Committee which jointly make most major decisions regarding programadministration including decisions on trainee appointments, mentor review and approval, and overall trainingprogram design, although the latter involves input from many others including the Dean, Associate Dean forGraduate and Medical Scientist Programs, CVTG faculty mentors, and an External Advisory Committee.Day-to-day administrative duties are carried out by Dr. Owens and the CVTG Program Administrator, MarySheffer. These duties include all trainee-related matters and program formation. The CVTG ProgramAdministrator maintains database and fellows’ records, coordinates recruiting, processes reimbursements,oversees fellows’ stipends and funding, oversees the program’s website, organizes fellows’ meetings with theDirector and Associate Directors, facilitates translational clinical experiences, and plans training programactivities.Two Associate Directors assist the program in three different capacities. The Associate Directors are appointedby Dr. Owens.Associate Director of Curriculum and WorkshopsThe Associate Director for Curriculum and Workshops, Dr. Brant Isakson, oversees CVTG Courses offered,including course content and emphasis, as well as coordinating scheduling to avoid conflicts with other crucialcourses and seminar series. These courses include Advanced Vascular Biology and Career Development.Associate Director of Scientific Programs and Student AdvisingThe Associate Director for Scientific Programs and Student Advising, Dr. Shayn Peirce-Cottler, assists theDirector in developing programmatic activities to promote interaction and scientific exchange between theCVTG fellows and to foster their development as scientists. These activities include participation in monthlyResearch in Progress meetings, grant brewing sessions, special workshops, annual progress report meetings,etc.Executive CommitteeThe Executive Committee is composed of the Director, Associate CVRC Director, two Associate CVTG Directors(Gary Owens, Norbert Leitinger, Brant Isakson, Shayn Peirce-Cottler), and the Program Administrator. TheCVTG Advisory Committee is responsible for reviewing and evaluating pre-doctoral applications whereas postdoctoral candidates are reviewed by the Executive Committee. Committee members may also be asked tointerview prospective trainees. The CVTG Advisory Committee is also responsible for reviewing and evaluatingeach fellow’s progress through the annual progress report and meeting. The purpose of these meetings is toreview the written progress report, discuss the fellow’s research progress, outline a timeline for completion oftraining, identify long term career plans, and identify any problems that may need further attention, includingissues with mentoring or funding. CVTG Steering Committee members do not sit in the meeting for their owntrainees.2021-2022 UVA CVTG Handbook page 4

Financial Support for CVTG Pre-doctoral FellowsCVTG Pre-doctoralFellows’ Benefits:Amounts reflect the 2021-2022StipendBase 32,500 ( 25,836 from the CVTG)Tuition & Fees3 Semesters of Graduate School (Fall, Spring, Summer)Health/Dental 3027 Health Insurance Subsidy (amount increases annually) *estimate* 283 Dental (from GPO) *estimate*Travel 1000 (up to) *See Attendance section*Books, software, &computer 750 (up to) *See Attendance section*1 journal subscription and 1 organization membership at trainee levelStipendThe current BIMS base stipend is 32,500 for fiscal year 2021-2022, with 25,836 provided from the NIH CVTGT32 HL007284. Student stipends may be higher than 32,500 based on numerous factors. If a student receivesan individual extramural fellowship such as an American Heart Association (AHA), Department of Defense(DOD), National Science Foundation (NSF), or National Research Service Award (NRSA) among others, studentscan request a merit increase to their stipend. If a fellow is awarded an extramural fellowship he/she may beeligible for a merit bonus stipend in the amount of 1,000. The process of requesting the merit increase is towrite to the BIMS Administrator, BIMS director, CVTG Director, and the mentor together to request the meritraise. If these individuals agree a merit supplement is warranted, it must be approved by the Associate Deanfor Graduate and Medical Scientist Programs (Dr. Janet Cross). Once a decision is made, the BIMSAdministrator sends information to the funding coordinator in the Graduate Programs Office to set it up. TheCVTG follows a traditional fiscal year calendar from July 1 to June 30 of the following year. Funding is allocatedby the FY. All fellows on the CVTG are supported by a monthly stipend.There are times during graduate years that a student can move from stipend (paid monthly) to wages (paidout bi-weekly). It will depend on the program and funding source which one a student will receive. Allstudents should stay in close contact with their BIMS Administrator to make sure they understand theirfunding situation.Tax statements are not provided to any student other than the monthly email sent stating that a deposit ispending. These should be retained for tax recording purposes. Pre-doctoral students can expect to hear fromvarious administrative people in May and June to ensure that funding is in place; if there are any concernsabout upcoming funding shifts, please do not hesitate to contact your BIMS Administrator or the CVTGProgram Administrator.2021-2022 UVA CVTG Handbook page 5

Tuition and FeesThe CVTG funds pre-doctoral fellow tuition and fees, while the fellow is on the CVTG. Tuition and fees will bepaid for three semesters (Fall, Spring, and Summer; semester order based on appointment start date) perappointment year.During the rest of the pre-doctoral fellows’ Graduate School training, Ph.D. Mentors are responsible for fullfinancial support of students. Sources of funding during this period include mentors’ research grants, supportfrom departmental or center funds, and/or individual extramural fellowships obtained by students.Health and Dental InsuranceThe current Graduate Programs policy is to provide coverage for the pre-doctoral fellow’s health and dentalinsurance. The fellow can pay an additional amount for family coverage.Students can enroll in the UVA Health Insurance Program through Chickering and the UVA Dental InsuranceProgram through United Concordia, both divisions of Aetna. Students much register annually for health anddental and are not automatically registered. When completing the online application, the system should notprompt students to pay. If this occurs, the student should notify their BIMS Administrator and try processingthe application a couple of days later. Should students elect to purchase other insurance, they should notifytheir BIMS Administrator and the CVTG Program Administrator, and then they must submit the properdocumentation quarterly for reimbursement within in the same fiscal year. Dental insurance is optional andstudents must complete an application annually and pay with a personal check by the October deadline. Acopy of the cancelled check is necessary in order to receive reimbursement. It is the responsibility of thestudent to submit and complete paperwork regarding health and dental insurance reimbursement.Short term coverage is available and a number of options are listed on the student health insurance website.Do not hesitate to contact the Assistant Director should you have an emergency situation. www.gradmed.comPlease refer to ml for more information.Travel and Book FundsFellows who have at least 80% attendance to program activities will be awarded up to 1000 in travel fundsand 200 book or computer program funds per appointment year. Please see the Attendance Policy in thesection CVTG Events for further details and requirements. Flights and conference registration can bepurchased prior to travel with the Program Administrator. Lodging, meals, car rental, taxi rides, etc must bereimbursed. Boarding passes, itemized receipts, and other travel information should be submitted to theProgram Administrator within 5 business days of returning from the trip. More travel information and detailscan be found at www.procurement.virginia.edu/pagetravel or by contacting the Program Administrator.Fellows may purchase books through the Program Administrator by emailing book titles, ISBNs, and whether aspecific edition is needed or the fellow may purchase a book and submit a receipt for reimbursement.Journal Subscription and Organization MembershipFellows who have at least 80% attendance to program activities and are in good standing are eligible for onejournal subscription and organization membership per appointment year. See the Program Administrator topurchase a subscription or membership.Items not covered by CVTG Funds:Vaccinations, thesis binding, research funds, testing fees, and instruments2021-2022 UVA CVTG Handbook page 6

Financial Support for CVTG Post-doctoral FellowsCVTG Post-doctoral Fellows’Benefits:Amounts reflect the FY21 budgetStipendYears of Relevant ExperienceStipend Amount* If advisors want to pay at ahigher level than what is allottedby the NIH CVTG, they maysupplement with non-NIH fundsonly.0 53,7601 54,1442 54,5403 56,7124 58,6085 60,7806 63,0367 65,292Tuition & FeesAs needed for coursesHealth/DentalLow or High Premium; Fellow covered, spouse/ children coverage to bepaid by Fellow; See chart below for chargesTravel 1000 (up to) *See attendance section*Books, software, & computer 750 (up to) *See attendance section*1 journal subscription, 1 organization membership at trainee level, 1 UVa gym membershipStipendThe current base stipend is set by the NIH at the above listed levels of experience based on appointment date.Advisors may choose to supplement the fellow with non-NIH funds. If a fellow is awarded an extramuralfellowship, he/she may receive a different stipend level. Post-doctoral fellows are paid by stipend around the6th of each month for that month. A Fellow may switch to a Research Associate with the awarding of anextramural fellowship, which will result in a pay schedule change. Please be aware of and in contact with theProgram Administrator to anticipate these changes.The CVTG follows a traditional fiscal year calendar from July 1 to June 30 of the following year. Funding isallocated by the FY. A form for direct deposit will be submitted along with appointment paperwork.Tax statements are not provided to any fellow other than the appointment letter and pay data form usedwhen setting up the appointment. These should be retained for tax recording purposes. Please &hhsearchterms %22taxes%22 for information aboutpostdoctoral tax issues.Post-doctoral fellows have to agree to “pay back” the first 12 months of their post-doctoral stipend. Thispayback can be in the form of one month of work in the field of science (including teaching and industry) forevery month up to 12 months that they received an NRSA postdoctoral fellow stipend. Note that the secondyear of a post-doctoral fellowship qualifies as a payback.2021-2022 UVA CVTG Handbook page 7

Tuition and FeesThe CVTG will fund pertinent tuition and fees for post-doctoral fellow courses, while the fellow is on the CVTG.Please submit in writing to the Director and the Program Administrator a request for tuition, coursedescription, and details of relevance and need.Health and Dental InsurancePostdoctoral Fellows have two health plan options: Value Health, a low-premium program similar to the Postdoctoral Fellow Low PlanChoice Health, a high-premium program similar to the Postdoctoral Fellow High PlanIn addition to choosing a health plan program, you must complete a spousal affidavit in order for yourspouse to be on your plan.UVa Health Plan Postdoctoral Fellows Monthly Premiums 2021New Plan NameSingleValue HealthChoice Health 501.50 559.00Employee Child(ren) 743.75 848.75Employee Spouse Family 1,028.50 1,163.00 1,481.75 1,678.00Travel and Book/Computer Program FundsFellows who have at least 80% attendance to program activities will be awarded up to 1000 in travel fundsand 200 book/computer program funds per appointment year. Please see the Attendance Policy in thesection CVTG Events for further details and requirements. Flights and conference registration can bepurchased prior to travel with the Program Administrator. Lodging, meals, car rental, taxi rides, etc must bereimbursed. Boarding passes, itemized receipts, and other travel information should be submitted to theProgram Administrator within 5 business days of returning from the trip. More travel information and detailscan be found at www.procurement.virginia.edu/pagetravel or by contacting the Program Administrator.Fellows may purchase books through the Program Administrator by emailing book titles, ISBNs, and whether aspecific edition is needed or the fellow may purchase a book and submit a receipt for reimbursement.Journal Subscription and Organization MembershipFellows who have at least 80% attendance to program activities and are in good standing are eligible for onejournal subscription and organization membership per appointment year. See the Program Administrator topurchase a subscription or membership.Intramural Sports and Athletic Facilities MembershipA request for a letter of authorization identifying the post-doctoral fellow who would like to use these facilitiesshould be sent to the Program Administrator. The authorization letter should be taken to The Director, IntraMural Sports and Recreation, Aquatic and Fitness Center, Whitehouse Road from 8:00 am – 5:00 pm Mondaythrough Friday. The annual charge for using these facilities is approximately 450. The CVTG can reimburseyou for this charge; please give or email a receipt to the Program Administrator. Details about all the facilities2021-2022 UVA CVTG Handbook page 8

available and their hours of operation are available by visiting http://www.virginia.edu/ims or calling 9243791.Office for Post-doctoral ProgramsThe Office for Post-doctoral Programs works on behalf of Post-doctoral Fellows at the University of Virginia,sends out relevant notices, and runs a career development seminar series. The tml has information regarding insurance, events, and links tohelpful resources. For questions regarding postdoctoral issues, please contact 243.2018 [email protected] not covered by CVTG Funds:Vaccinations, thesis binding, testing fees, and instruments2021-2022 UVA CVTG Handbook page 9

UVA CVTG Courses and EventsAttendance Required Courses and EventsVascular Biology Course (BIMS 8052, 8053)DetailsAnnually, in the SpringAdvanced Physiology Course (BIMS 8040, 8041)Annually, in the Spring.Ethics Course (BIMS 7100)A short course offered every Spring.Cardiovascular Research Center Seminar SeriesMost Thursdays during academic year at 11:00 AM-12:00 pm in MR53005, unless otherwise noted or via Zoom. Special seminars mayoccur on other days, at other times, or during the summer.Annual Robert M. Berne Distinguished LectureAnnually, in the Fall/Spring. Date/Location TBD.Research in Progress Sessions3rd Thursday of every month, 4:00-5:30 pm MR6 2502 or via ZoomGrant Brewing WorkshopAttend all trainee grant brewing sessions and present at least one ofyour fellowship grants sometime during the year. Date/LocationTBD.Trainee Run Career Development CourseIn the Spring, Mondays at 10:00 AM, Location/Dates TBD. (variousdays possible)Translational Clinical/Observation Experience2 half-day experiences per year, individually scheduled. (see listing)Recommended Courses and EventsDetailsCVTG Faculty Grant Brewing WorkshopsSelect dates and times during the year.International CollaborationsOpportunities individually arranged. Attend and present at Nationaland International research conferences. TBDThere are several CVTG activities to supplement the training provided by degree granting graduate programsand bench work. CVTG activities are extremely important in promoting the unique development of scientistsand to allow them to identify with a cohort group with similar goals and expectations. Attendance is requiredunless otherwise noted.Vascular Biology (BIMS 8052, 8053)Vascular Biology is a broad interdisciplinary course considering the basis for vascular function from aphysiological and pathophysiological perspective. Topics include basic microcirculatory function, smoothmuscle and endothelial cell function and development, capillary exchange, inflammatory processes, leukocyteendothelial cell interactions, and the pathophysiology of atherogenesis. Topics such as vascular control,angiogenesis, and inflammatory responses of the cardiovascular system will be highlighted. Prerequisite: Onecourse in mammalian physiology and one in cell biology. The course is split into two modules.Advanced Physiology Course (BIMS 8040, 8041)The course will integrate background cellular and molecular knowledge into organ systems and whole animal,function. It is intended to provide the ability to integrate knowledge at the molecular level into function, thefoundation of translational-based research. The physiology to be covered will include the nervous system,metabolism and endocrine systems. The course is split into two modules.Ethics Course (BIMS 7100)2021-2022 UVA CVTG Handbook page 10

Beginning in 1989, the National Institutes of Health introduced a requirement that institutions provide aprogram of instruction in the responsible conduct of research (NIH Guide for Grants and Contracts, Volume 18,Number 45, 1989). This was later expanded to require that all fellows on NIH training grants should receiveinstruction in the responsible conduct of research. The course covers: conflict of interest, responsibleauthorship, policies for handling misconduct, policies regarding the use of human and animal subjects, anddata management. This course is designed to help trainees consider each of these areas and therein formulatean understanding of responsible conduct in research. Trainees must take an Ethics Course at each career stage(graduate student, post-doctoral fellow, etc) or at least once every four years.Cardiovascular Research Center Seminar SeriesThe Robert M. Berne Cardiovascular Research Center Seminar Series is a long-running and well-establishedseminar series hosting many renowned scientists and clinicians each year. Speakers are selected to span thebroad range of cardiovascular research, and to educate the trainees in matters beyond their immediate benchresearch needs. Fellows and former fellows have the opportunity to meet with invited guests one-on-one orfor breakfast or lunch. Trainees also invite and host up to four seminar speakers per year.Annual Robert M. Berne Distinguished LectureThe Annual Robert M. Berne Distinguished Lecture is a highlight of Cardiovascular Research Center, which isgiven in the fall, by a scientist of outstanding caliber. The list of past Lecturers includes three Nobel Prizewinners. The Berne Lecture thus becomes the culmination of the scientific presentations of the year. Thetrainees will attend the Lecture, Reception, and also meet with the speaker in a roundtable lunch

The training program supports 8 pre-doctoral and 7 post-doctoral trainees. The first year of training for graduate students is done in one of 7 Biomedical Sciences (BIMS) Graduate Programs after which the trainee chooses a research mentor and a PhD Program for completing their