Water in Mesitylene (0.1 mg/g) 4222-a 4222001-13/10/16-1/7Safety Data Sheet1. Identification of the Substance/Mixture and the SupplierSupplierAddressDepartmentPerson in ChargePhone NumberEmergencyContact: The National Institute of Advanced Industrial Science and Technology: 1-3-1, Kazumigaseki, Chiyoda, Tokyo, Japan: Reference Material Office, Center for Quality Management ofMetrology, The National Metrology Institute of Japan: Certified Reference Material Staff: 029-861-4059Fax Number : 029-861-4009: Same as abovemplePrepared on : October 16, 2013Revised on : April 1, 2015ID Number : 4222001Identity of: Certified reference material: NMIJ CRM 4222-aSubstance/MixtureWater in Mesitylene (0.1 mg/g)(Water in Mesitylene (0.1 mg/g))Recommended Use of the: This reference material is standard solution for waterChemical and Restrictionanalysis which uses mesitylene as matrix, and it can be used,on Usein water quantification by using Karl Fischer (KF) moisturemeter, for calibration of analysis equipment as well as qualitycontrol of analysis and validation of analysismethod/equipment. Do not use this reference material forother purposes than testing/research.2. Hazards IdentificationFlammable liquidSkin corrosion/irritationSerious eye damage/Eye irritationSpecific target organtoxicity/Systemic toxicity(Single exposure)Aspiration hazardToxic to the aquaticenvironment (Acute)Toxic to the aquaticenvironment (Chronic)SaGHS Classification:: Hazard Category 3: Hazard Category 2: Hazard Category 2B: Hazard Category 3 (for anesthesia): Hazard Category 1: Hazard Category 2: Hazard Category 2GHS Label Element:Signal Word:DangerHazards Statement: Flammable liquid and vaporCauses skin irritationCauses eye irritationMay cause drowsiness or dizzinessMay be fatal if swallowed and enters airwaysToxic to aquatic lifeToxic to aquatic life with long lasting effects

Water in Mesitylene (0.1 mg/g) 4222-a 4222001-13/10/16-2/7[Safety Precaution]Use only outdoors or a well-ventilated area.Use only non-sparking tools.Avoid release to the environment.Wash hands thoroughly after handling this reference material.Take precautions against electrostatic discharge.Keep away from ignition sources such as heat/sparks/open flames/hotsurfaces. – No smoking.Avoid breathing gas/mist/vapor/spray.Use protective gloves and eye protector/face protector.Use explosion-proof electrical/ventilating/lighting equipment.Ground container and receiving equipment.Keep container tightly closed.[Action]If swallowed:Get medical advice/attention immediately.If in eyes: Rinse cautiously with water for several minutes. Removecontact lenses, if present and easy to do. Continue rinsing.Get medical advice/attention if eye irritation prolongsIf feeling unwell, get medical advice/attention.If inhaled:Remove victim to fresh air and keep at rest in a positioncomfortable for breathing.If on skin: Wash with plenty of soap and water. Take off/Remove allcontaminated clothing. Wash contaminated clothing before reuse.If skin irritation occurs: Get medical advice/attention.[Storage]Store in light-shielded clean environment at temperature rangingfrom 15 C to 30 C.[Disposal]Comply with applicable legislation and local government ordinance.Entrust disposal of this reference material to a professional wastedisposal company licensed by prefectural governor.mpleOther HazardsStatement:PrecautionaryStatement:The other hazards than the above do not result in classification or arenot covered by the GHS.3. Composition/Information on IngredientsSa: SubstanceSubstance/Mixture: MesityleneChemical Identity: 1,3,5-trimethyl benzeneSynonym: 98 % or moreContentChemical Formula orMolecular formula: C6H3(CH3)3Structural Formula: 120.19Molecuar WeightID Number in Official Gazette Act on the Evaluation of Chemical Substances andRegulation of Their Manufacture, etc.: (3)-7The Industrial Safety and Health Law: 3-3427:CAS Number108-67-8: MesityleneHazardous Ingredient4. First-Aid MeasuresIf in eyes: Rinse away with plenty of water immediately for 15 minutes ormore. Get medical advice/attention immediately.

Water in Mesitylene (0.1 mg/g) 4222-a 4222001-13/10/16-3/7If on skinIf inhaledIf swallowedExpected Acute andDelayed SymptomMost CriticalCharacteristic andSymptomProtection ofFirst-Aid Responder: Wash with plenty of soap and water. Get medical advice/attentionif inflammation occurs.: Remove victim to fresh air and keep warm and at rest. Get medicaladvice/attention immediately.: Make victim drink plenty of water or salt solution to inducevomiting. Get medical advice/attention immediately.: Cause mental confusion, coughing, dizziness, lethargy, headache,sore throat and vomiting if inhaled.:: First-aid responders must use personal protective equipment suchas rubber gloves and tightly-sealed goggle.5. Fire-Fighting MeasuresFire-Specific HazardsSpecific Fire-FightingMethodmpProtection ofFire-Fighters: Powder, Carbon dioxide (CO2), Foam (alcohol-resistant foam),Dry sand: As irritating or toxic fume (or gas) is generated in the case offire, use appropriate personal protective equipment to avoidbreathing it.: Eliminate ignition sources at the origin of a fire and put out fireby using extinguishing media. Remove movable containerspromptly to a safe place. In the case of immovable containers,cool their surroundings with sprayed water.: Carry out fire-fighting from the windward in order to avoidbreathing hazardous gas. Use personal protective equipmentsuch as fireproof clothing, heat-resistant clothing, protectiveclothing, compressed air open-circuit self-contained breathingapparatus, compressed oxygen closed-circuit self-containedbreathing apparatus, rubber gloves and rubber boots.leExtinguishing Media6. Accidental Release MeasuresPersonal PrecautionSaPersonal ProtectiveEquipment andEmergencyProcedures: Remove potential ignition sources from the vicinity promptly.Get fire-fighting kit ready to be prepared for ignition.: Ventilate the affected areas thoroughly, if it is in an indoorenvironment, until the clean-up operation is completed.Use appropriate personal protective equipment during theoperation to avoid skin contact of splash etc. and inhalation of dustand gas.: Take precautions to prevent spillage from draining into rivers adversely impact the environment. Make it sure toappropriately treat contaminated wastewater in order to preventuntreated wastewater from being released into the surroundingenvironment.: Collect spillage in empty containers by getting it adsorbed towiping cloth, rag or earth and sand, etc. Rinse away the remainswith plenty of water.: Mark the restricted area with rope etc. to keep out unauthorizedpeople. Carry out the clean-up operation from the windward andmake people on the leeward side evacuate. Take precautions aswet surface is slippery.EnvironmentalPrecautionsRecovery andNeutralizationPrevention ofSecondary Disaster7. Handling and Storage PrecautionsHandlingEngineeringPrecautions: Strict ban on fire. Keep away from hot surfaces and sparks.Avoid contact with strong oxidizers.

Water in Mesitylene (0.1 mg/g) 4222-a 4222001-13/10/16-4/7: Store in light-shielded clean environment at temperature rangingfrom 15 C to 30 C.Use only explosion-proof electrical equipment in storage area.Ground all equipment.Strict ban on fire.Avoid storing near strongly oxidizing substances and ignitionsources.: GlassmpStorageAppropriate StorageConditions: Use local ventilation system and keep container tightly closed ifvapor/mist is generated.: Avoid rough handling such as turning over, dropping, giving ashock to or dragging containers.Prevent spill, overflow and scattering, and avoid vaporgeneration.Keep container tightly closed after use.Wash hands, face etc. thoroughly and gargle after handling thisreference material.Restrict drinking, eating and smoking to a designated area.Do not bring gloves and other contaminated personal protectiveequipment into staff room.Make a place handling this reference material a restricted area tokeep out unauthorized people.Use appropriate personal protective equipment to avoidinhalation and contact with eyes, skin and clothing.Use local ventilation system in indoor handling areas.leLocal and GeneralVentilationPrecautions for SafeHandlingSafe ContainerPackaging Material8. Exposure Controls/Personal ProtectionSaThreshold Limit ValueNot specifiedPermissible Concentration・ACGIH TLV-TWA: TWA 25 ppm・Value recommended by Japan: Not specifiedSociety for Occupational Health・OSHA PEL TWA: Not specifiedEngineering Controls: Local or general ventilation equipmentVentilation/ExhaustSafety Control/: Install safety shower and facilities to rinse eyes and to washGas Detectionhands in the vicinity of a place handling this reference materialand label them clearly.: Strict ban on fire.Storage PrecautionsKeep away from strongly oxidizing substances and ignitionsources.Personal Protective Equipment (PPE): Chemical cartridge respirator for organic gas, Compressed airRespiratory Systemopen-circuit self-contained breathing apparatus: Protective glovesHands: Eye protectorEyes: Protective clothing, Protective bootsSkin and Body9. Physical and Chemical Properties

Water in Mesitylene (0.1 mg/g) 4222-a �:LiquidColorlessPeculiar aromatic odorNo data available-44.72 C164.72 C43 CUpper limit: 6.1 vol%, Lower limit: 0.9 vol%2 hPa (20 C)4.1:0.865 g/ml(20 ):・Partition Coefficient :n-octanol/water log Po/w・Spontaneous ibility・Viscosity Coefficient・Specific Gravity of Vapor:Insoluble in water (0.002 g/ml water), Soluble in ethanoland benzene3.93:550 C:No data available:::No data available1.154 cP (25 C)4.17 (Air 1)mple・Appearance, etc.・Color・Odor・pH・Melting Point・Boiling Point・Flash Point・Explosive Range・Vapor Pressure・Relative Vapor Density(Air 1)・Specific Gravity or BulkSpecific Gravity・Solubility10. Stability and ReactivitySa Stability・Stable under normal conditions Reactivity・May react if in contact with strong oxidizer Conditions to Avoid・Sunlight, heat, open flames, high temperature, sparks, static electricity, other ignitionsources Hazardous Decomposition Products・Carbon monoxide (CO)11. Toxicological InformationAcute ToxicitySkin Corrosion/IrritationSerious Eye Damage/Eye IrritationRespiratorySensitizationOral Rat LC50: 24 g/m3/4HAbdominal cavity Guinea pig LDL0: 1303 mg/kgLC50 4,900 ppm (equivalent to 4 hours) was obtained whencalculation formula was applied to result of (mist) inhalationexposure study using rats: LC50 24 mg/l (4 hours)Result of skin irritation study using rabbits: “erythema and edemawere observed and skin irritation was reported in accordance withEEC classification” and “medium-level irritation”“Light irritation” was observed in eye irritation study usingrabbits (duration period is unknown)Human health effects: It is reported that erethism, tension,uneasiness and bronchial asthma were observed in 27 workersinvolved in production of products containing 30 % of thisreference material and 50 % of 1,2,4-trimethyl benzene for several

Water in Mesitylene (0.1 mg/g) 4222-a 4222001-13/10/16-6/7Skin SensitizationGerm Cell MutagenicityMay be fatal if swallowed and enters airways12. Ecological InformationleCarcinogenicitySpecific target organtoxicity/Systemictoxicity (Singleexposure)Aspiration hazardyears and exposed to hydrocarbon vapor (concentration: 10-60ppm). As the products also contain other isomers, however, thesesymptoms cannot be specifically attributed to this referencematerial.Cannot be classified due to insufficient data.Cannot be classified due to insufficient data.No inter-generation mutagenicity study, No germ cell in vivomutagenicity studyNegative in somatic cell in vivo mutagenicity study (micronucleusstudy)No data availableExperimental animals: “At 5,075-7,105 ppm, sedation effects wereobserved. At 7,105-9,135 ppm, loss of reflex and damage toneutral nerve were observed.”mpPersistence and Degradability・Not degraded by microorganisms etc.0% by BODBioaccumulative Potential・Concentration rate (BCF): 23 to 342 (Concentration: 150 µg/l), 42 to 328(Concentration: 15µg/l)Ecotoxicity・Oryzias latipes LC50: 8.6 mg/l/48H・Crustacea (Daphnia magna) LC50: 6000 µg/l/48H13. Disposal Considerations:Incineration methodUse incinerator equipped with scrubber.Dispose of this reference material in accordance with applicablelegislation and local government ordinance.When the above-mentioned treatments are not possible, entrustdisposal of residual waste to a professional waste disposal companylicensed by prefectural governor.Dispose of containers after thoroughly removing their contents.SaResidual WasteContaminatedContainer andPackage:14. Transport InformationUN NumberUN ClassificationShipping NamePacking GroupICAO/IATAMarine PollutantPrecautions:::::::2325Class 31,3,5-trimethyl benzenePG ⅢGlass 3 Grade ⅢHazardous liquid material (Class X)Transport this reference material carefully while keeping it away fromdirect sunlight and fire and preventing accidental release due tofalling, overturning, etc.

Water in Mesitylene (0.1 mg/g) 4222-a 4222001-13/10/16-7/715. Applicable Legislationmple Fire Defense Law・Dangerous substance Class 4 Class 2 petroleum (insoluble in water) Danger Rating 3 Pollutant Release and Transfer Register Act (PRTR Act)・Class 1 Designated Chemical Substance (Government Order 297) Industrial Safety and Health Law・Enforcement Order Appendix 1-4 Dangerous Materials Flammables・Article 57-2 (Enforcement Order: Article 18-2) Hazardous substance whose name, etc.must be notified: No.404 Road Act・Enforcement Order 19-13 Restricted-Traffic Substances Marine Pollution Prevention Law・Enforcement Order Appendix 1 Hazardous Liquid Materials Class X Ship Safety Law・Dangerous Material Rule Article 3 Dangerous Material Announcement Appendix 1Flammable Liquids Civil Aeronautics Act・Enforcement Regulation Article 194 Dangerous Material Announcement Appendix 1Flammable Liquids Port Regulation Law・Enforcement Regulation Article 12 Dangerous Material Announcement FlammableLiquids Living Environment Item (Enforcement Order Article 3-1)・[Emission Limit]160 mg/l or less (Daily average: 120 mg/l or less)Note: Comply with add-on emission limit, if any, separately stipulated by ordinance etc. Export Trade Control Order・Appendix 1-16 (Catch-all Controls) Class 29 Organic ChemicalsHS Code (Export Statistics Item Number): 2902.90-200 “Cyclic hydrocarbon – Others –Others”16. Other InformationSaOthersThe information in this Safety Data Sheet is not intended to be exhaustive and is based oncurrently-available information and data. The precautions given in this data sheet areapplicable only to normal handling conditions. When handling this reference material underspecial conditions etc., it is recommended to take safety precautions appropriate to eachspecific application and context of use. This Safety Data Sheet (SDS) is intended to provideinformation and not intended to guarantee anything in handling the reference material.This Safety Data Sheet (SDS) is prepared based on JIS Z7253, and presents identicalinformation to Material Safety Data Sheet (MSDS) prepared based on JIS Z7250:2010.

Store in light-shielded clean environment at temperature ranging from 15 C to 30 C. [Disposal] Comply with applicable legislation and local government ordinance. Entrust disposal of this reference material to a professional waste disposal company licensed by prefectural governor. The other hazards than the above do not result in classification or are not covered by the GHS. 3. Composition .