Transcription

MALGORZATA MARJANSKACenter for Magnetic Resonance ResearchUniversity of Minnesota2021 6th ST SEMinneapolis, MN 55455citizenship: USA/[email protected]: (612) 625-4894Fax: (612) 626-2004Education:Ph.D. University of California, Berkeley - Physical ChemistryMay 2002Professor Alexander Pines, AdvisorThesis Title: “Quantum Logic Gates, Local Field, Selective Excitation and Structural Studies of DipolarCouplings in Oriented Molecules”B.S.Loyola University of Chicago (summa cum laude)Major: Chemistry; Minor: MathematicsMay 1997Awards and Fellowships:Honorary Mention, National Science Foundation, 1997Departmental Honors in Chemistry, Loyola University of Chicago, 1997Merck Index Award, Loyola University of Chicago, 1997AT&T Bell Labs Summer Fellowship, Lucent Technologies, 1996Undergraduate Award in Analytical Chemistry, Loyola University of Chicago, 1996Sophomore Award in Mathematics, Loyola University of Chicago, 1995W.I.S.E.R. Summer Research Fellowship, Loyola University of Chicago, 1994Fr. Morrisey Medal, best undergraduate in chemistry, Loyola University of Chicago, received each year 1994-1997Research experience:Sep. 2013 topresentCenter for Magnetic Resonance Research, University of Minnesota – Assistant Professor– developed DNP applications in the brain– developing spectroscopic methods for in vivo applications at high fields (brain)Oct. 2004 toSep. 2013Center for Magnetic Resonance Research, University of Minnesota – Research Associate/AssistantProfessor without Tenure Track– developed DNP applications in the brain– developing spectroscopic methods for in vivo applications at high fields (brain, leg muscles)– overseeing collection, responsible for analysis and interpretation of spectroscopy data for Alzheimer’smouse projectOct. 2002 toOct. 2004Center for Magnetic Resonance Research, University of Minnesota – Postdoctoral Fellow, Supervisor:Professor Kamil Ugurbil– designed novel spectroscopic editing methods for in vivo applicationsSep. 1997 toJun. 2002University of California, Berkeley and Lawrence Berkeley National Laboratory – Graduate StudentAssistant, Advisor: Professor Alexander Pines– developed a novel approach for performing selective excitation in strongly coupled systems– developed generalized methods for the measurement of the 19F-1H dipolar couplings in nematic liquidcrystalline samples– demonstrated the viability of liquid crystals as a platform for quantum computingJan. to Jul.1997Argonne National Laboratory – Researcher, Supervisor: Dr. Lester Morss– evaluated the properties of new chelating agents with respect to the acidity and metal complexationability1

Summer 1996 AT&T Bell Laboratories/Lucent Technologies – Summer Fellow, Supervisor: Dr. Peter Mirau– characterized self-assembly of polymer films using solid-state NMRMay 1994 toSep. 1995Loyola University of Chicago - Undergraduate Research, Advisor: Professor Alanah Fitch– studied the transport of water soluble porphyrins through nano-sized channels constructed from clayfilms using cycling voltammetryTeaching experience:Fall 2006Lecturer, BPhy8293 – Directed Study, Advanced Topics in Biomedical Magnetic Resonance Imaging andSpectroscopy (University of Minnesota)– instructed the course with four other people (P Bolan, C Corum, P-G Henry, P-F Van de Moortele)– taught all lectures related to spectroscopic techniques, reviewed current literature on the topic, chosetopics for student presentationsFall 2005Lecturer, BPhy8147 – Advanced Physics of MRI (University of Minnesota)– instructed the course with four other people (P Bolan, C Olman, K Ugurbil, P-F Van de Moortele)– taught all lectures related to magnetic resonance spectroscopyFall 2003Lecturer, BPhy8293 – Directed Studies in MR Research (University of Minnesota)– instructed the course with one other person (C Olman)– lectured on variety of topics in magnetic resonance, designed and instructed laboratoriesFall 1999Head Teaching Assistant, CHM 1A – General Chemistry (U. C. Berkeley)– supervised 43 teaching assistants for class of 1300 students– wrote exams and weekly quizzes for the course– held weekly discussion sessions and gave review sessionsFall 1998Graduate Student Instructor, CHM 125 – Physical Chemistry Laboratory (U. C. Berkeley)– gave one-on-one, hands-on instruction of physical chemistry laboratory techniques to 30 students– gave oral exams, graded written laboratory reportsFall 1997Graduate Student Instructor, CHM 1A – General Chemistry (U. C. Berkeley)– prepared and led weekly discussions, graded homework and exams for 30 students– supervised laboratory sessions for 30 students1995 to 1997Teaching Assistant – Department of Chemistry (Loyola University of Chicago)– trained undergraduate students to operate 300 MHz high-field solution spectrometer as part ofintroducing NMR spectroscopy at the earliest practical level into the undergraduate curriculumAffiliations:2003 to presentInternational Society of Magnetic Resonance in Medicine2000 to 2002Group AMPEREPublications:1. Christine Wiebking, Niall W Duncan, Brice Tiret, David J Hayes, Malgorzata Marjanska, Julien Doyon, MalekBajbouj, Georg Northoff, “GABA in insula – a predictor of the neural response to interoceptive awareness.” –NeuroImage – doi: 10.1016/j.neuroimage.2013.04.042.2

2. Evan A Weitz, Cutler Lewandowski, Eric D Smolensky, Malgorzata Marjanska, Valerie Pierre, “Amagnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy” – ACS Nano 7(2013) 5842-5849.3. Eric Smolensky, Hee-Yun Park, Yue Zhou, Malgorzata Marjanska, Mauro Botta, Valerie Pierre, “Scaling laws atthe nano size: the effect of particle size and shape on the magnetism and relaxivity of iron oxide nanoparticle contrastagents.” - Journal of Material Chemistry B, 22 (2013) 2818-2828.4. Ryan L Muetzel, Malgorzata Marjanska, Paul F. Collins, Mary Petrosko, Romain Valabregue, Edward J. Auerbach,Kelvin O. Lim, Monica Luciana, “In vivo 1H magnetic resonance spectroscopy in young-adult daily marijuana users.”– NeuroImage Clinical 2 (2013) 581-589.5. Niall W. Duncan, Christine Wiebking, Brice Tiret, Malgorzata Marjanska, Dave J. Hayes, Oliver Lyttleton, JulienDoyon, Georg Northoff. “Glutamate concentration in the medial prefrontal cortex predicts resting-state corticalsubcortical functional connectivity in humans.” – Plos One 8 (2013) e60312.6. Sara Tremblay, Vincent Beaulé, Sebastien Proulx, Louis De Beaumont, Malgorzata Marjanska, Julien Doyon,Alvaro Pascual-Leone, Maryse Lassonde, Hugo Théoret. “The relationship between transcranial magnetic stimulationmeasures of intracortical inhibition and spectroscopy measures of GABA and glutamate glutamine.” – Journal ofNeurophysiology 109 (2013) 1343-1349. PMID: 232214127. Malgorzata Marjańska, Stephane Lehéricy, Romain Valabrègue, Traian Popa, Yulia Worbe, Margherita Russo,Edward J. Auerbach, David Grabli, Cecilia Bonnet, Cecile Gallea, Mathieu Coudert, LydiaYahia-Cherif, MarieVidailhet, Sabine Meunier. “Brain dynamic neurochemical changes in dystonic patients: A magnetic resonancespectroscopy study.” – Movement Disorders 28 (2013) 201-209. PMID: 232390768. Małgorzata Marjańska, Lynn E. Eberly, Gregor Adriany, Sarah N. Verdoliva, Michael Garwood, Lisa Chow,“Influence of foot orientation on the appearance and quantification of 1H magnetic resonance muscle spectra obtainedfrom the soleus and the vastus lateralis” – Magnetic Resonance in Medicine 68 (2012) 1731-1737. PMID: 22298295PMCID: PMC33818549. Małgorzata Marjańska, Thomas Z. Teisseyre, Nicholas W. Halpern-Manners, Yi Zhang, Isabelle Iltis, VikramBajaj, Kamil Ugurbil, Alexander Pines, Pierre-Gilles Henry, “Measurement of Arterial Input Function inHyperpolarized 13C Studies”– Applied Magnetic Resonance 43 (2012) 289-297.10. Eric D. Smolensky, Malgorzata Marjanska, Valerie C. Pierre, “A responsive particulate MRI contrast agent forcopper (I): optimal cluster size for maximum response”– Dalton Transactions 41 (2012) 8039-8046. PMID:2258234211. Hermien Kan, Mahidol Aranee, Matthias van Osch, Dinesh Deelchand, Pierre-Gilles Henry, MalgorzataMarjanska, Mark van Buchem, Andrew Webb, Itamar Ronen, “Differences in apparent diffusion coefficients ofneuronal metabolites between grey and white matter in the human brain measured at 7 T” – Magnetic Resonance inMedicine 67 (2012) 1203-1209. PMID: 2208356212. Pierre-Gilles Henry, Dinesh Deelchand, Isabelle Iltis, Malgorzata Marjanska, Gulin Oz, Alexander Shestov, JulienValette, “In vivo 13C NMR spectroscopy and metabolic modeling: methodology.” Chapter in Advances inNeurobiology, edited by Rolf Gruetter and In-Young Choi, Springer, 2012.13. Dinesh Deelchand, Pierre-Gilles Henry, Kamil Ugurbil, and Małgorzata Marjańska, “Measurement of transverserelaxation times of J-coupled metabolites in the human visual cortex at 4 T” – Magnetic Resonance in Medicine 67(2012) 891-897. PMID: 2174879914. Małgorzata Marjańska, Edward J. Auerbach, Romain Valabrègue, Pierre-François Van de Moortele, GregorAdriany, Michael Garwood, “Localized 1H NMR Spectroscopy in Different Regions of Human Brain In Vivo at 7 T:3

T2 Relaxation Times and Concentrations of Cerebral Metabolites”– NMR in Biomedicine 25 (2012) 332- 339. PMID:2179671015. Uzay Emir, Edward J. Auerbach, Pierre-Francois Van de Moortele, Malgorzata Marjanska, Kamil Ugurbil, MelissaTerpstra, Ivan Tkac, Gulin Oz, “Regional Neurochemical Profiles in the Human Brain measured by 1H MRS at 7Tesla using Local B1 Shimming” – NMR in Biomedicine 25 (2012) 152-160. PMID: 2176638016. Joseph F. Poduslo, Kristi Hultman, Geoffrey L. Curran, Gregory M. Preboske, Ryan Chamberlain, MałgorzataMarjańska, Michael A. Garwood, Clifford R. Jack, and Thomas Wengenack, “Targeting Vascular Amyloid inArterioles of Alzheimer’s Disease Transgenic Mice with Amyloid Beta Protein Antibody Coated Nanoparticles” –Journal of Neuropathology & Experimental Neurology 70 (2011) 653-661. PMID: 2176054017. Thomas M. Wengenack, Denise A. Reyes, Geoffry L. Curran, Brent J. Borowski, Joseph Lin, Gregory M. Preboske,Silvina S. Holasek, Emily J. Gilles, Ryan Chamberlain, Malgorzata Marjanska, Clifford R. Jack Jr., MichaelGarwood, Joseph F. Poduslo, “Regional differences in MRI detection of amyloid plaques in AD transgenic mousebrain,” NeuroImage 54 (2011) 113-122. PMID: 2072854618. Malgorzata Marjanska, Isabelle Iltis, Alexander A. Shestov, Dinesh K. Deelchand, Christopher Nelson, KamilUgurbil, Pierre-Gilles Henry, “In Vivo 13C Spectroscopy in the Rat Brain using Hyperpolarized [1-13C]pyruvate and[2-13C]pyruvate,” Journal of Magnetic Resonance 206 (2010) 210-218. PMID: 206851419. Gulin Oz, Christopher Nelson, Dee M. Koski, Pierre-Gilles Henry, Malgorzata Marjanska, Dinesh K. Deelchand,Ryan Shanley, Lynn E. Eberly, Harry T. Orr, H. Brent Clark, “Noninvasive detection of presymptomatic andprogressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1,” Journal of Neuroscience, 30(2010) 3831-3838. PMID: 2022001820. Lana G. Kaiser, Malgorzata Marjanska, Gerald B. Matson, Isabelle Iltis, Seth D. Bush, Brian J. Soher, SusanneMueller, Karl Young, “1H MRS detection of glycine residue of reduced glutathione in vivo,” Journal of MagneticResonance, 202 (2010) 259-266. PMID: 2000513921. Fei Du, Yi Zhang, Isabelle Iltis, Malgorzata Marjanska, Xiao-Hong Zhu, Pierre-Gilles Henry, and Wei Chen, “InVivo 1H MRS to Quantify Anesthetic Effects of Pentobarbital on Cerebral Metabolism and Brain Activity in Rat,”Magnetic Resonance in Medicine, 62 (2009) 1385-1393.22. Ryan Chamberlain, Denise Reyes, Geoffrey L. Curran, Malgorzata Marjanska, Thomas M Wengenack, Joseph F.Poduslo, Michael Garwood, Clifford R. Jack Jr., “Comparison of amyloid plaque contrast generated by T 2-weighted,T2*-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease,”Magnetic Resonance in Medicine, 61 (2009) 1158-1164.23. Malgorzata Marjanska, Matt Waks, Carl J. Snyder, J. Tommy Vaughan, “Multinuclear NMR Investigation of ProbeConstruction Materials at 9.4 T,” Magnetic Resonance in Medicine, 59 (2008) 936-938.24. Isabelle Iltis, Malgorzata Marjanska, Fei Du, Deanne M. Koski, Xiao-Hong Zhu, Kamil Ugurbil, Wei Chen, andPierre-Gilles Henry, “1H MRS in the Rat Brain under Pentobarbital Anesthesia: Accurate Quantification of In VivoSpectra in the Presence of Propylene Glycol,” Magnetic Resonance in Medicine, 59 (2008) 631-635.25. Malgorzata Marjanska, Pierre-Gilles Henry, Kamil Ugurbil, Rolf Gruetter, “Editing through Multiple Bonds –Threonine Detection,” Magnetic Resonance in Medicine, 59 (2008) 245-251.26. Stefan Posse, Ricardo Otazo, Arvind Caprihan, Juan Bustillo, Hongji Chen, Pierre-Gilles Henry, MalgorzataMarjanska, Charles Gasparovic, Chun Zuo, Vincent Magnotta, Bryon Mueller, Paul Mullins, Perry Renshaw, KamilUgurbil, Kelvin O. Lim, Jeffry R. Alger, “Proton Echo Planar Spectroscopic Imaging of J-Coupled Resonances inHuman Brain at 3 and 4 Tesla,” Magnetic Resonance in Medicine, 58 (2007) 236-244.4

27. Mircea C. Dobre, Kamil Ugurbil, Malgorzata Marjanska, “Determination of the Blood Relaxation Time (T1) atHigh Magnetic Field Strengths,” Magnetic Resonance Imaging, 25 (2007) 733-735.28. Clifford R. Jack, Jr., Malgorzata Marjanska, Thomas M. Wengenack, Denise A. Reyes, Geoffrey L. Curran, JosephLin, Gregory M. Preboske, Joseph F. Poduslo, and Michael Garwood, “Magnetic Resonance Imaging of Alzheimer’sPathology in the Brains of Living Transgenic Mice: A New Tool in Alzheimer’s Disease Research,” Neuroscientist,13 (2007) 38-48.29. Stéphane Lehéricy, Malgorzata Marjanska, Lilia Mesrob, Serge Kinkingnehun, “Magnetic Resonance Imaging ofAlzheimer’s Disease,” European Radiology, 17 (2007) 347-362.30. Melissa Terpstra, Malgorzata Marjanska, Pierre-Gilles Henry, Ivan Tkac, and Rolf Gruetter, “Detection of anAntioxidant Profile in the Human Brain In Vivo using Double Editing Within (DEW) Localized NMR Spectroscopy,”Magnetic Resonance in Medicine, 56 (2006) 1192-1199.31. Kamil Ugurbil, Gregor Adriany, Can Akgün, Peter Andresen, Wei Chen, Michael Garwood, Rolf Gruetter, PierreGilles Henry, Malgorzata Marjanska, Steen Moeller, Pierre-Francois Van de Moortele, K Prüssmann, Ivan Tkac, J.Tommy Vaughan, Florian Wiesinger, Essa Yacoub, Xia-Hong Zhu, “High magnetic fields for imaging cerebralmorphology, function and biochemistry.” In: Robitaille PM and Berliner LJ, editor. Biomedical Magnetic Resonance:Ultra High Field Magnetic Resonance Imaging. Volume 26. New York: Springer; 2006. p. 285-342.32. Pierre-Gilles Henry, Gregor Adriany, Dinesh Deelchand, Rolf Gruetter, Malgorzata Marjanska, Guling Oz,Elizabeth R. Seaquist, Alexander Shestov, Kamil Ugurbil, “In Vivo 13C NMR Spectroscopy and Metabolic Modelingin the Brain: a Practical Perspective,” Magnetic Resonance Imaging, 24 (2006) 527-539.33. Pierre-Gilles Henry, Malgorzata Marjanska, Jamie D. Walls, Julien Valette, Rolf Gruetter, Kamil Ugurbil, “ProtonObserved Carbon-Edited NMR Spectroscopy in Strongly Coupled Systems,” Magnetic Resonance in Medicine, 55(2006) 250-257.34. Kathleen E. Chaffee, Malgorzata Marjanska, Boyd M. Goodson, “NMR Studies of Chloroform@cryptophane-Aand Chloroform@bis-cryptophane Inclusion Complexes Oriented in Thermotropic Liquid Crystals,” Solid State NMR,29 (2006) 104-112.35. Malgorzata Marjanska, Geoffrey L. Curran, Thomas M. Wengenack, Pierre-Gilles Henry, Robin L. Bliss, Joseph F.Poduslo, Clifford R. Jack Jr., Kamil Ugurbil, Michael Garwood, “Monitoring Disease Progression in TransgenicMouse Models of Alzheimer’s Disease with Proton Magnetic Resonance Spectroscopy,” Proceedings of the NationalAcademy of Science USA, 102 (2005) 11906-11910.36. Charles H. Cunningham, Daniel B. Vigneron, Malgorzata Marjanska, Albert P. Chen, Duan Xu, Ralph E. Hurd,John Kurhaniewicz, Michael Garwood and John M. Pauly, “Sequence Design for MR Spectroscopic Imaging ofProstate Cancer at 3 T,” Magnetic Resonance in Medicine, 53 (2005) 1033-1039.37. Malgorzata Marjanska, Pierre-Gilles Henry, Patrick J. Bolan, Brooks Vaughn, Elizabeth R. Seaquist, Rolf Gruetter,Kamil Ugurbil and Michael Garwood, “Uncovering Hidden In Vivo Resonances Using Editing Based on LocalizedTOCSY,” Magnetic Resonance in Medicine, 53 (2005) 783-789.38. Liang-shi Li, Malgorzata Marjanska, Gregory H. J. Park, Alexander Pines and A. Paul Alvisatos, “Isotropic-LiquidCrystalline Phase Diagram of CdSe Nanorod Solution,” Journal of Chemical Physics, 120(3) (2004) 1149-1152.39. Malgorzata Marjanska, Boyd M. Goodson, Franca Castiglione, and Alexander Pines, “Inclusion ComplexesOriented in Thermotropic Liquid Crystalline Solvents Studied with Carbon-13 NMR,” Journal of Physical ChemistryB, 107 (2003) 12558-12561 (cover article).5

40. Malgorzata Marjanska, Robert H. Havlin and Dimitris Sakellariou, “Coherent Averaging and Correlation ofAnisotropic Spin Interactions in Oriented Molecules,” part of “NMR of Ordered Liquids” edited by Elliot Burnell andCornelis A. de Lange, Kluwer Scientific, 2003.41. Malgorzata Marjanska, Franca Castiglione, Jamie D. Walls, and Alexander Pines, “Measurement of DipolarCouplings in Partially Oriented Molecules by Local Field NMR Spectroscopy with Low-Power Decoupling,” Journalof Magnetic Resonance, 158 (2002) 52-59.42. Jamie D. Walls, Malgorzata Marjanska, Dimitris Sakellariou, Franca Castiglione, and Alexander Pines, “SelectiveExcitation in Dipole Coupled Systems,” Chemical Physics Letters, 357 (2002) 241-248.43. Malgorzata Marjanska, Isaac L. Chuang, and Mark G. Kubinec, “Demonstration of Quantum Logic Gates in LiquidCrystal Nuclear Magnetic Resonance,” Journal of Chemical Physics, 12 (2000) 5095-5099.44. Malgorzata Marjanski, Mohan Srinivasarao, Peter Mirau, “Solid-state Multipulse Proton Nuclear MagneticResonance Characterization of Self-assembling Polymer Films,” Solid State Nuclear Magnetic Resonance, 12 (1998)113-118.45. Alanah Fitch, Sungho Park, Yunlong Wang, Malgorzata Marjanski, and Pal Joo, “Intelligent Design of Thin ClayFilms; Transport and Tailoring”, Book Chapter, International Clay Conference, A. Yamagishi and A. Aramata, Eds.,1997, Hokkaido University Press, Hokkaido, Japan.46. Alanah Fitch, Yunlong, Sungho Park, Malgorzata Marjanski, “Molecular Basis for Transport in NanoporousMedia: Utility of Clay-Modified Electrodes” in “New Directions in Electroanalytical Chemistry,” eds: Leddy, Johna,Wightman, Mark, The Electrochemical Society, Inc., Pennington: 1996.Invited Talks:1. Malgorzata Marjanska, “Hyperpolarized 13C Spectroscopy in Rat Brain at 9.4 T and Localized 1H Spectroscopy inHuman Brain at 7 T” – Martinos Center, Massachusetts General Hospital, March 14, 20122. Malgorzata Marjanska, “1H Spectroscopy Techniques and Applications at High Field” – McLean Hospital, March 13,2012.3. Malgorzata Marjanska, “Hyperpolarized 13C spectroscopy in rat brain” – 3rd International Meeting on DynamicNuclear Polarization, Lausanne, Switzerland, September 7-10, 20114. Malgorzata Marjanska, “Hyperpolarized 13C spectroscopy in the rat brain”, University of New Mexico, Department ofPhysics, December 2, 2010.5. Malgorzata Marjanska, “HyperpolarizedMedicine, December 3, 2010.13C spectroscopy in the rat brain”, University of New Mexico School of6. Malgorzata Marjanska, “Magnetic Resonance Imaging and Spectroscopy for Understanding Alzheimer’s Disease”,Medtronic, September 28, 2010.7. Malgorzata Marjanska, “Methodology of MRS in Transgenic Mouse Models” – 18th International Society forMagnetic Resonance Research in Medicine Meeting, Stockholm, May 1-7, 20108. Malgorzata Marjanska, “Measurement of Intramyocellular Lipid – Challenges and Opportunities” – Mayo CTSANMR Spectroscopy Workshop, October 28, 20089. Malgorzata Marjanska, “Localized Spectroscopy in Different Regions of Human Brain at High Magnetic Field” – 6thBi-annual Minnesota Workshop on High Field MR Imaging and Spectroscopy and MR Imaging of Brain Function,October 4-7, 20076

10. Malgorzata Marjanska, “Magnetic Resonance Imaging and Spectroscopy for Understanding Alzheimer’s Disease”,Centre for NeuroImaging Research, Pitie-Salpetriere Hospital, Paris, France, July 16, 200711. Malgorzata Marjanska, “Magnetic Resonance Imaging and Spectroscopy for Understanding Alzheimer’s Disease”,NEUROSPIN, France, July 11, 200712. Malgorzata Marjanska, Geoffrey L. Curran, Thomas M. Wengenack, Pierre-Gilles Henry, Robin L. Bliss, Joseph F.Poduslo, Clifford R. Jack, Jr., Kamil Ugurbil, Michael Garwood, “Monitoring Disease Progression in TransgenicMouse Models of Alzheimer’s Disease with MRS”, European Society for Magnetic Resonance in Medicine andBiology, 23rd Annual Meeting, Warszawa, Poland, September 21-23, 200613. Malgorzata Marjanska, “NMR Spectroscopy for Understanding Alzheimer’s Disease” – University of California atBerkeley, Alexander Pines’ laboratory – August 4, 200614. Malgorzata Marjanska, Geoffrey L. Curran, Thomas M. Wengenack, Joseph F. Poduslo, Clifford R. Jack Jr., KamilUgurbil, Michael Garwood “NMR Spectroscopy for Understanding Alzheimer Disease”, Symposium and TrainingXIV: New Frontiers in Metabolic Imaging, Southwestern Medical Center, April 20, 200615. Malgorzata Marjanska, “Progression of Alzheimer’s Disease in Transgenic Mouse Models Monitored with 1H MRS”,VA Medical Center, Minneapolis, February 3, 200616. Malgorzata Marjanska, “Monitoring Disease Progression on Transgenic Mouse Models of Alzheimer’s Disease Using1H MRS”, Department of Neurology, University of Minnesota, November 3, 200517. Malgorzata Marjanska, Geoffrey L. Curran, Thomas M. Wengenack, Joseph F. Poduslo, Clifford R. Jack Jr., KamilUgurbil, Michael Garwood, “Proton Magnetic Resonance Spectroscopy in Alzheimer Mouse Model”, 5 th Bi-annualMinnesota Workshop on High Field MR Imaging and Spectroscopy and MR Imaging of Brain Function, October 1316, 200518. Malgorzata Marjanska, “Uncovering In Vivo Resonance using Magnetic Resonance Spectroscopy”, Department ofChemistry, Southern Illinois University at Carbondale, August 31, 200519. Malgorzata Marjanska, “Uncovering Hidden In Vivo Resonances using 1D-TOCSY-LASER Spectroscopy”, NewYork Structural Biology Center, NY, October 18, 200420. Malgorzata Marjanska, Jamie Walls, Dimitris Sakellariou, Franca Castiglione, and Alexander Pines, “SelectiveExcitation in Strongly Coupled Systems”, 85th CSC Conference and Exhibition, Vancouver, Canada, June, 2002Presentations:1. Najib Allaili, Romain Valagregue, Malgorzata Marjanska, Pauline Delaveau, Eric Bardinet, Martiza Jabourian, JudithLaredo, Stephane Lehericy, Philippe Fossati, “Hippocampal Choline Level predicts symptomatic improvement withAgomelatine in major depressive disorder: a 3 Tesla single voxel spectroscopy study” Society of BiologicalPsychiatry, 68th Annual Scientific Conference, San Francisco, May 6-18, 2013 – oral presentation2. Najib Allaili, Romain Valagregue, Malgorzata Marjanska, Pauline Delaveau, Eric Bardinet, Martiza Jabourian, JudithLaredo, Philippe Fossati, Stephane Lehericy, “Hippocampal Choline Level predicts symptomatic improvement withAgomelatine in major depressive disorder: a 3 Tesla single voxel spectroscopy study” 21st International Society forMagnetic Resonance Research in Medicine Meeting, Salt Lake City, April 20-26, 2013, pg. 737 – oral presentation3. Malgorzata Marjanska, Pierre-Gilles Henry, “In vivo time courses of brain TCA cycle intermediate observes usinghyperpolarized magnetic resonance”, 54th Experimental Nuclear Magnetic Resonance Conference, Asilomar, April14-19, 2013 - poster7

4. Vincent Beaule, Sara Tremblay, Louis de Beaumont, Julien Doyon, Malgorzata Marjanska, Maryse Lassonde, HugeTheoret, “Long-term investigation of primary motor cortex metabolism in concussed athletes” - Human BrainMapping, Beijing, China, June 10-14, 20125. Sara Tremblay, Vincent Beaule, Louis de Beaumont, Julien Doyon, Malgorzata Marjanska, Maryse Lassone, HugoTheoret, “On the relationship between TMS-derived measures of GABAB synaptic activity and 1H MRS measure ofglutamate and GABA in primary motor cortex” – Human Brain Mapping, Beijing, China, June 10-14, 20126. Uzay E. Emir, Malgorzata Marjanska, Dinesh Deelchand, Melissa Terpstra, “Metabolite 1H transverse relaxation ratesmeasured in the healthy young versus elderly human brain at 4 T” 20th International Society for Magnetic ResonanceResearch in Medicine Meeting, Melbourne, May 5-11, 2012, pg. 1820 – poster7. Malgorzata Marjanska, Alexander Shestov, Pierre-Gilles Henry, “Brain metabolism under different anesthesia usinghyperpolarized [1-13C]pyruvate 20th International Society for Magnetic Resonance Research in Medicine Meeting,Melbourne, May 5-11, 2012, pg. 1692 – poster8. Malgorzata Marjanska, Stephen D. Weigand, Geoffry L. Curran, Thomas M. Wengenack, Joseph F. Poduslo, MichaelGarwood, Clifford R. Jack, Jr., “Correlation between Plaque Counts and Metabolite Concentrations in TransgenicMouse Model of Alzheimer’s Disease” - 20th International Society for Magnetic Resonance Research in MedicineMeeting, Melbourne, May 5-11, 2012, pg. 1797 – poster9. Alaa Houri, Bonnie Klimes-Dougan, Malgorzata Marjanska, Kelvin O. Lim, and Kathryn Cullen, “Brain metabolitelevels in the anterior cingulate cortex in adolescents with major depressive disorder” 67th Annual Society ofBiological Psychiatry, Philadelphia, PA, May 3-5, 2012. - poster10. Michael-Paul Schallmo, Scott R. Sponheim, Malgorzata Marjanska, Cheryl A. Olman, “Schizophrenia AffectsContextual Modulation during Contour Detection” – Society of Neuroscience, Washington D.C., November 12-16,2011 – poster11. Sabine Meunier, Malgorzata Marjanska, Romain Valabregue, Traian Popa, Yulia Worbe, Margherita Russo, EdwardJ. Auerbach, David Grabli, Cecilia Bonnet, Marie Vidailhet, Stephane Lehericy, “The neurochemical profile ofwriter’s cramp and its changes after non-invasive 5 Hz cortical stimulation: a 3 tesla magnetic resonance spectroscopystudy” – European Congress of Clinical Neurophysiology, Rome, Italy, June 20-26, 2011 – poster12. Sabine Meunier, Malgorzata Marjanska, Romain Valabregue, Traian Popa, Yulia Worbe, Margherita Russo, EdwardJ. Auerbach, David Grabli, Cecilia Bonnet, Marie Vidailhet, Stephane Lehericy, “The neurochemical profile ofwriter’s cramp and its changes after non-invasive 5 Hz cortical stimulation: a 3 tesla magnetic resonance spectroscopystudy” – Movement Disorder Society, Toronto, Canada, June 5-10, 2011 - poster13. Alaa Houri, Kristina Reigstad, Caroline Schimunek, Bonnie Klimes-Dougan, Malgorzata Marjanska, Kelvin Lim,Kathryn Cullen, “Magnetic Resonance Spectroscopy and Depression in Adolescent Girls” – Society of BiologicalPsychiatry 66th Annual Meeting, San Francisco, May 12-14, 2011 – poster14. Ulrike Dydak, Jun S. Xu, Malgorzata Marjanska, Stefan Posse, “3D GABA Spectroscopic Imaging using MEGAPEPSI” – 19th International Society for Magnetic Resonance Research in Medicine Meeting, Montreal, May 7-13,2011, pg. 1428 – poster15. Malgorzata Marjanska, Edward J. Auerbach, Romain Valabregue, Pierre-Francois Van de Moortele, Gregor Adriany,Michael Garwood, “T2 Relaxation Times in the Human Brain at 7 T” – 19th International Society for MagneticResonance Research in Medicine Meeting, Montreal, May 7-13, 2011, pg. 1439 – poster16. Malgorzata Marjanska, Stephen D. Weigand, Geoffry L. Curran, Thomas M. Wengenack, Josef F. Poduslo, Michael.Garwood, and Clifford R. Jack, Jr., “Detection of Treatment Effects with 1H MRS in Transgenic Mouse Model ofAlzheimer’s Disease” – 19th International Society for Magnetic Resonance Research in Medicine Meeting, Montreal,May 7-13, 2011, pg. 2233 – poster8

17. Dinesh K. Deelchand, Pierre-Gilles Henry, Kamil Ugurbil, Malgorzata Marjanska, “Transverse relaxation times ofstrongly J-coupled metabolites with LASER and CP-LASER in the rat brain” – 19th International Society forMagnetic Resonance Research in Medicine Meeting, Montreal, May 7-13, 2011, pg. 2258 – poster18. Dinesh K. Deelchand, Isabelle Iltis, Gregor Adriany, Emily Colonna, Malgorzata Marjanska, Kamil Ugurbil, PierreGilles Henry, “Neurochemical profile of the striatum and hippocampus in mice at 16.4 T using in vivo 1H MRSspectroscopy” – 19th International Society for Magnetic Resonance Research in Medicine Meeting, Montreal, May 713, 2011, pg. 3439 – poster19. Malgorzata Marjanska, Ryan Chamberlain, Gregory Preboske, Linda Kotilinek, Thomas M. Wengenack, Joseph F.Poduslo, Karen H. Ashe, Michael Garwood, Clifford R. Jack, Jr, “Magnetic Resonance Biomarkers ofNeurodegeneration in a Transgenic Mouse Model of Alzheimer’s Disease” – 10th International Conference onAlzheimer’s Disease, Honolulu, July 10-15, 2010 - poster20. Ute Goerke, Malgorzata Marjanska, Manda Vollmers, Isabelle Iltis, Pierre-Gilles Henry, Kamil Ugurbil, “fMRI usinga Hyperpolarized Tracer Molecule” – 18th International Society for Magnetic Resonance Research in MedicineMeeting, Stockholm, May 1-7, 2010 – talk21. Najib Allaïli, Malgorzata Marjanska, Edward J. Auerbach, Eric Bardinet, Philippe Fossati, Romain Valabrègue,Stéphane Lehéricy, “Single Voxel 1H Spectroscopy in the Human Hippocampus at 3 T Using LASER: AReproducibility Study” – 18th International Society for Magnetic Resonance Research in Medicine Meeting,Stockholm, May 1-7, 2010 – poster22. Ulrike Dydak, Malgorzata Marjanska, Stefan Posse, “High-Speed GABA Mapping in Human Brain with MEGAPEPSI at 3 Tesla” – 18th International Society for Magnetic Resonance Research in Medicine Meeting, Stockholm,May 1-7, 2010 – poster23. Isabelle Iltis, Dinesh Kumar Deelchand, Malgorzata Marjanska, Gregor Adriany, Manda Vollmers, Kamil Ugurbil,Pierre-Gilles Henry, “[1-13C]lactate Signal Derived from Hyperpolarized [1-13C]pyruvate Originates from the Brain,Not from the Blood” – 18th International Society for Magnetic Resonance Research in Medicine Meeting, Stockholm,May 1-7, 2010 – poster24. Hermien E. Kan, Matthias J.P. van Osch, Maarten J. Versluis, Aranee Techawiboonwong, Dinesh K. Deelchand,Pierre-Gilles Henry, Malgorzata Marjanska, Mark A. van Buchem, Andrew G. Webb, Itamar Ronen, “A

22. Ryan Chamberlain, Denise Reyes, Geoffrey L. Curran, Malgorzata Marjanska, Thomas M Wengenack, Joseph F. Poduslo, Michael Garwood, Clifford R. Jack Jr., "Comparison of amyloid plaque contrast generated by T 2-weighted, T 2 *-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease,"