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NIRSHIMACNew Treatment Research Facility Projectat HIMACKoji NodaResearch Center for Charged Particle TherapyNational Institute of Radiological SciencesIPAC10, Kyoto, JAPAN, 25th May, 2010
NIRSHIMACContents1.Introduction2.Design and specifications3.Overview of project status4.Summary
IntroductionNIRSHIMACPhysical Advantage of Heavy IonHigh longitudinal doselocalization due to theBragg peak.580Cproton4Dose (GyE)100Relative dose (%)Lateral biological dose distribution32160040-8-6-4-20246lateral position (cm)200051015Depth in water (cm)C ionngam m a-rayprotonHigh transverse doselocalization due to the lowscattering.8
IntroductionNIRSBiological AdvantageHIMAC4ＳｉＨ5ＣHeBiological Dose (GyE)3R B E, O ERBiological Depth-Dose Distribution of 6cm SOBP21RBEO ER4CNe3ProtonTumor2Normal tissue1001101001000 （LETkeV /μ）LET (keV/μm)LET dependence on RBE, OER100000510Depth in Water1520
NIRSHIMACIntroductionMilestone of HIMAC Radiotherapy1984: Heavy ion therapy project started under“ National Comprehensive 10-year Strategyfor Cancer Control “.1988-93: Construction of HIMAC.1994 : Carbon-ion RT started at 21st June 19942003 : approved ”Highly Advanced Medical Technology ”2004-05 : Design and R&D for Downsized C-ion RT Facility2006-09 : Construction of Pilot Facility at Gunma Uni.2010: 1st Patient treated at Gunma at 16th March 2010.2006-10 : New Treatment Research Facility Projectfor further development of HIMAC treatment.
IntroductionNIRSHIMACHIMAC facility Ion species: High LET (100keV/μm) charged particles Range:30cm in soft tissue Maximum irradiation area:22cmΦ Dose rate:5Gy/min Beam direction:horizontal, verticalHIMAC (Heavy Ion Medical Accelerator in Chiba)He, C, Ne, Si, Ar800MeV/u (Si)
NIRSHIMACIntroductionMilestone of HIMAC Radiotherapy1984: Heavy ion therapy project started under“ National Comprehensive 10-year Strategyfor Cancer Control “.1988-93: Construction of HIMAC.1994 : Carbon-ion RT started at 21st June 19942003 : approved ”Highly Advanced Medical Technology ”2004-05 : Design and R&D for Downsized C-ion RT Facility2006-09 : Construction of Pilot Facility at Gunma Uni.2010: 1st Patient treated at Gunma at 16th March 2010.2006-10 : New Treatment Research Facility Projectfor further development of HIMAC treatment.
IntroductionNIRSHIMACProgress of treatment number800Num of Treatments700600500Treatment Period: 43 wks1st Term（Apr〜Aug）:18.5wks2nd Term（Sept〜Feb）:24.5wksTreatment: 4 days per week4003002001000949596979899 0 1 2 3 4 5 6 7 8 9FY
NIRSHIMACIntroductionMilestone of HIMAC Radiotherapy1984: Heavy ion therapy project started under“ National Comprehensive 10-year Strategyfor Cancer Control “.1988-93: Construction of HIMAC.1994 : Carbon-ion RT started at 21st June 19942003 : approved ”Highly Advanced Medical Technology ”2004-05 : Design and R&D for Downsized C-ion RT Facility2006-09 : Construction of Pilot Facility at Gunma Uni.2010: 1st Patient treated at Gunma at 16th March 2010.2006-10 : New Treatment Research Facility Projectfor further development of HIMAC treatment.
4. Compact FacilityNIRSHIMACGunma University Heavy-Ion Medical CenterTreatment RoomSynchrotron10Ghz-ECRInjector LinacAPF-IH
NIRSHIMACIntroductionMilestone of HIMAC Radiotherapy1984: Heavy ion therapy project started under“ National Comprehensive 10-year Strategyfor Cancer Control “.1988-93: Construction of HIMAC.1994 : Carbon-ion RT started at 21st June 19942003 : approved ”Highly Advanced Medical Technology ”2004-05 : Design and R&D for Downsized C-ion RT Facility2006-09 : Construction of Pilot Facility at Gunma Uni.2010: 1st Patient treated at Gunma at 16th March 2010.2006-10 : New Treatment Research Facility Projectfor further development of HIMAC treatment.
IntroductionNIRSMotivationHIMACHIMAC therapy needs to be upgraded.Upgrading irradiation system- raster scanning system- rotating gantry systemUpgrading control systemUpgrading patient handling systemUpgrading treatment planning systemFurther development of heavy-ion therapy- Adaptive therapy- Intensity modulated Ion Therapy (IMIT)New treatment facility projectNewfacilityHIMACHospital
IntroductionNIRSHIMACMotivation adaptive therapyIntra & interfractional changes from time resolved imaging (seconds to days) using CT/FPDdevices could be feed-back to the treatment planning. The rich information could extend toreplan, 4D plan and patient registration etc.
IntroductionNIRSMotivation IMITHIMACIMIT plan example0Gantry with 3D scanning makes it possibleto realize Intensity Modulated Ion Therapy(IMIT).deg288 deg72 degPTV IMITPTV SnglGTV IMITGTV SnglCRD IMITCRD Sngl10080Volume [%]0 deg604020216 deg0020406080100144 deg120Dose [%]- Improved dose conformity and steeper dose gradients- Further reduction of integral dose- Less sensitivity to range uncertainties and other sources of uncertainty
NIRSHIMACContents1.Introduction2.Design and specifications3.Overview of project status4.Summary
Design & SpecNIRSHIMACDesign and specificationsHIMACNew facility1.2.3.4.5.6.Ion species: 12C, 16O (11C, 15O)Irradiation method: Hybrid raster scanningRange: 30cm in waterMaximum irradiation area: 22cm squareDelivered Intensity: 107 – 109 pps (for C ions)Treatment rooms: 3 2 H&V 1 rotating gantry
R&D WorkNIRS3D Scanning MethodHIMACAdaptive Therapy by 3D Scanning1) Beam utilization efficiency 100％2) Irradiation on irregular shape target3) No bolus & collimator1) Sensitive beam error2) Longer irradiation time3) Sensitive to organ motionMonitorScannerRange ShifterBeamDose distributionof pencil beam
R&D WorkNIRS3D Scanning MethodHIMACAdaptive Therapyby 3DScanningRescanningwithGated Irradiation1001201401601) Beam utilization efficiency 100％2) Irradiation on irregular shape target3) No bolus & collimator18020000.1-400.20.3-200.40.41) Sensitive beam error2) Longer irradiation time3) Sensitive to organ eShifter1.1BeamDose distributionof pencil beam
Design & SpecNIRSHIMACFast 3D ScanningIn order to realize the rescanning with gating within acceptable irradiation time,we have studied following strategy.1. Treatment planning for fast scanning 5 22. Modification of acc. operation3. Fast scanning magnet（A) 10100-times speed up !!y (m m )500-50-500x (m m )50（B）（C）
Design & SpecNIRSFast scanning systemHIMAC 3D scanning irradiation Max field size220 mm2 Max SOBP150 mm Max energy430 MeV/u Moving targetOK beam size3 6 mm (1σ) Ene. changeRSFDesign and R&D work were carried out.Vertical lineHorizontal lineRoom EBeam test : Dec. 2008 Feb. 2010
Design & SpecNIRSHIMACFast scanning systemDesign and R&D work were carried out.Vertical lineHorizontal lineRoom EBeam test : Dec. 2008 Feb. 2010
Design & SpecNIRSHIMACFast scanning systemDesign and R&D work were carried out.Vertical lineScanning MagnetHorizontal lineRoom EBeam test : Dec. 2008 Feb. 2010
Design & SpecNIRSHIMACFast scanning systemDesign and R&D work were carried out.Vertical linePos. Moni.Horizontal lineRoom EBeam test : Dec. 2008 Feb. 2010Dose Moni
Design & SpecNIRSHIMACFast scanning systemDesign and R&D work were carried out.Vertical lineRange ShifterHorizontal lineRoom EBeam test : Dec. 2008 Feb. 2010
Design & SpecNIRSHIMACGantry design1) IMIT2) Reduction of Patient’s Load 3D scanning irradiation Max field size150 mm2 Max SOBP150 mm Max energy430 MeV/u Moving targetOK beam size3 6 mm (1σ) Ene. changeRSF Total weight350 ton
Design & SpecNIRSHIMACFloor planTreatment rooms : 3Simulation rooms : 2Preparation rooms: 6
NIRSHIMACContents1.Introduction2.Design and specifications3.Overview of project status4.Summary
OverviewNIRSHIMACBuildingMar. 2010, new treatment building construction has been completed.
OverviewNIRSHIMACBuildingApril, 2010Mar. 2010, new treatment building construction has been completed.
OverviewNIRSHIMACTreatment room / Simulation roomSimulation roomTreatment room
OverviewNIRSHIMACTreatment room / Simulation roomSimulation roomTreatment roomApril, 2010
OverviewNIRSHIMACEntranceTreatment HallPreparation room
OverviewNIRSHIMACEntranceTreatment HallPreparation room
OverviewNIRSHIMACBeam line devicesBeam line dipole magnetQuadrupole magnetInstallation of devices is in progress.
NIRSHIMACContents1.Introduction2.Design and specifications3.Overview of project status4.Summary
SummaryNIRSHIMACSummary9 Construction of the building is completed.9 Performance of 3D rescanning is verified.9 Installation & commissioning will be carried out in this year.9 First patient is scheduled in next March.
NIRSAcknowledgementHIMACknaThfuyouoyornoitnetr at
2004-05 : Design and R&D for Downsized C-ion RT Facility 2006-09 : Construction of Pilot Facility at Gunma Uni. 2010 : 1st Patient treated at Gunma at 16th March 2010. 2006-10 : New Treatment Research Facility Project for further deve
