Knoebel Institute for Healthy AgingQuality in Life, Wellness and CommunityDr. Lotta Granholm-Bentley, PhD/DDSExecutive Director

KIHA Strategic Goals The mission is to create and implement solutions foraging issues through multidisciplinary research,education and outreach. Interdisciplinary research programs Competency of current and future workforce Support business innovation Intergenerational programs

The silver “Tsunami” The age group over 75increases the most Life span has increased Cure for some age-relatedconditions Huge lack of work force Technology, service, andinfrastructure

What is Aging?1)2)3)4)Increase in mortality with agePhysiological changes/functional declineIncreased disease but aging is also wisdom and experienceAgeism

Workforce needs in aging Health care and social assistance Hospitality Transportation Technology Financial Industry

Centenarians Jean Calment Oldest recorded 1875–1997Jeanne Louise Calment: longest confirmedhuman lifespan on record, living to the age of 122years, 164 days

Is the glasshalf full orhalf empty?Most important trait: Physical activityPlant-based dietFamilySocial networkGardeningNo smokingComic written by Larry Lambert; illustratedby Jerry King.

9 traits shared by Blue zonesTo make it to age 100, youhave to have won thegenetic lottery. But mostof us have the capacity tomake it well into our early90’s and largely withoutchronic disease. As theCentenariansdemonstrate, the averageperson’s life expectancycould increase by 10-12years by adopting a BlueZones lifestyle.

Neurological disorders increase with agingStrokeAlzheimerParkinson’s disease

Alzheimer’s Disease 5.4 million Americans SC high incidence African Americans vulnerable One in five women and one in 10men AD by age 85


AD risk factors:

'AD Gene Panel' Some believe one can calculate risk for AD Panel uses 9 genes for inflammation and cholesterolmetabolism Categorize as low-high risk for AD Wide range of predisposition genesPercentage ofthe population ateach risk levelbased alzheimers.php

Gene therapy and Alzheimer’sUsing NGF-viralvectors to replacea neuro-hormonethat is lost in theAlzheimer brain.Replenishing thisprotein canincrease survivalrate and slowprogression ofdisease.Lancet NeurologyDeWitt et al2011

Alzheimer treatment Some drugs available to slow progression90 experimental treatments being testedTake care of your cardiac disease and diabetesExerciseEat less cholesterol/more antioxidantsTrain the brain

New early detection method MRI or PET imaging Biomarkers in blood or CSF Postmortem studies of n

What are exosomes?Aurelie LedreuxEric Hamlett

Alzheimer biomarkersin Down syndromeP-(S396)-Tau levels by AgeA 1 - 4 2 ( n o r m a liz e d ) p g /m l22C o n tro lDS2018161412108642P - ( S 3 9 6 ) - T a u ( n o r m a l iz e d ) p g / m lAβ1-42 levels by Age40C o n tr o lDS3530252015105000510 15 20 25 30 35 40 45 50 55 60 65 70 75 800510 15 20 25 30 35 40 45 50 55 60 65 70 75 80AGEDown syndromeAGEControls

Other areas of tech development Robotics (social bots, health care, transportation) Transportation (autonomous vehicles, Uber, Lyft, etc.) Financial industry (Easier online banking, assessmentof financial acuity, money management, etc.) Potential barriers towards using computerized systems

Dementia and Driving Early stages some people are able to keep driving People with dementia often do not know they arehaving driving problems Navigation problems Autonomous vehicles could prolong driving

Not just negative effects of aging on driving Older drivers have wisdom and experience Aware of limitations and impairments An Advanced driver assistance system (ADAS)more effective in older than younger drivers(Dotzauer et al., 2015) No driving in rush hour or darkness

Technology to help older drivers Car can identify objects and movement patterns Issue warning of collision Prepare for impact (safety features) Vehicle to vehicle communication Robotics and artificial intelligence Infrastructure communicationVolvo Cars Safety Center –Thomas Broberg

Autonomous vehicles and aging AVs will make "aging in place" more possible for theelderly – close mobility gap Japan's first extensive tests of autonomous cars in2016 – target older citizens The goal is to give the aging nation's elderly citizensa way to get around The Drive Me trial inGothenburg (automatedXC90s) Intellisafe AutonomousDriving program The first drivers will receivetheir cars in Dec. 2017. VolvoCEO Håkan Samuelsson

Aging in Place Travel needs by categories: Primary mobility needs (shops, services, health care) Secondary mobility needs (social needs,independence) Tertiary mobility needs (relaxation, visiting nature)Isolation

Smart Home technology Home automation or domotics a smart home Control and automation of lighting, heating,ventilation, air conditioning, and security Test homes are being created for SMARTHome research (USC)

Minka houseDr. Bill Thomas: A compact, digitally native, modular,panelized house that is both affordable and easy to livein. It seemed right to call this model the “Minka”because that is the Japanese word for “a house forregular people.”

Financial acuity and dementia Reduced financial acuityearliest sign of dementia Develop novel technology tomeasure financial planningcapacity in older adults Develop new and bettermeasurements and toolsDr. Eric Chess, Director

Concussion and dementia The link between brain injury and dementiacontroversial May lead to increased risk for Alzheimer’s disease Develop new technology to measure long-termeffects of concussions on balance and brain health Collaboration: Athletic Dep, Psychology, Engineering,KIHA, Chemistry

What are we hoping to do? Determine when safe to return to play Determine future risk for Alzheimer/CTE Find new technology for side-line diagnosisChanges in: Dynamic Balance Impulse control Biomarkers for Alzheimer

Thriving, not surviving Innovations addressing isolation, life purpose, food,healthcare quality, safety, and transportation Wearable devices, coupled with analytics, can improvepassive communication between older adults andcaregivers Changes in activities of daily living (ADLs), as tracked byCarePredict’s systemSocial robot RyanDr. Mohammad MahoorUniversity of Denver

Technology development Aging in place technology watch

Technology positively affects thebottom line How can senior housing and communities putinnovation into action today? How can developers make it easier for them toadopt innovation? create a positive impact on both the operations andfinancial health of senior living communities determine best practices, deliver care outcomes,manage risk in outcome-based risk-sharing caremodels, and retain staff

Resources Aging2.0 OPTIMIZE, 14-15 November, annually attractsthe top thinkers and doers in innovation and aging. Brings together academia, designers, developers,investors, and senior care executive visionaries torevolutionize the aging experience. Project X-ITE - Interdisciplinary project allowing students and facultythe opportunity to explore innovation, technology, andentrepreneurship

If you want one year of prosperity, grow grain.If you want 10 years of prosperity, grow trees.If you want 100 years of prosperity, grow people.Ancient Chinese proverb

Intellisafe Autonomous Driving program The first drivers will receive their cars in Dec. 2017. . Home automation or domotics a smart home Control and automation of lighting, heating, ventilation, air conditioning, and security Test homes are being created for SMARTHome