qEEG-Pro ManualFor use in the U.S.A.André W. Keizer, PhDv1.7 July 2018Version 1.7 Copyright 2018 qEEG-Pro BV, All rights reserved

T ABLE OF CONTENT1. Indications for use32. Potential adverse effects33. FFT Absolute Power44. Z-scored FFT Absolute Power5Appendix 1. qEEG-Pro calculation details12.1 qEEG-Pro normative database data collection12.2 qEEG-Pro EEG data analysis667Appendix 2. Practical guide for uploading raw EEGA3.1 Compatible devicesA3.3 Client sensitive information and Data securityA3.4 Instructional Videos, Expert Coaching and Support881010References12Version 1.72

1. Indications for useThe qEEGpro system is to be used by qualified medical or qualified clinical professionals for thestatistical evaluation of the human electroencephalogram (EEG). Federal law restricts this device tosale by or on the order of a licensed practitioner.2. Potential adverse effectsPotential adverse effects of the use of the device are known if the qEEG-Pro is used as a standalone diagnostic system in the absence of other clinical data from more traditional means ofpatient evaluation. Relying only upon the use of a single index (such as relative power or thetopological maps alone) without reviewing the traditional EEG, the epochs selected for analysis,or the complete set of statistical summary tables is also contraindicated and a source ofpotential error. Additional sources of error could arise from selecting EEG representative ofother states, such as drowsiness or eyes-open EEG when comparing to an eyes closed database.Additionally, it is possible that errors will occur through the purposeful falsification of symptomsin the patient history and patient age.Version 1.73

3. FFT Absolute PowerThe qEEG-Pro report contains topoplots of the absolute power (in microvolts squared), whichare depicted for each 1 Hz frequency bin, starting with 1 Hz and ending with 40 Hz. Eachfrequency bin ranges from -.5 to .5 Hz. For example: The 12 Hz bin ranges from 11.5 to12.5 Hz.Figure 1. Example of theFFT Absolute Poweranalysis.Version 1.74

4. Z-scored FFT Absolute PowerThe qEEG-Pro report contains topoplots of the Z-scored absolute power for each 1 Hzfrequency bin, starting with 1 Hz and ending with 40 Hz. The sample of the normativedatabase consists of 200 subjects that have the lowest age difference compared with the ageof the client, with an ‘age resolution’ of 6 months.Figure 2. Example of theZ-scored FFT AbsolutePower analysis.Version 1.75

Appendix 1. qEEG-Pro calculation details12.1 qEEG-Pro normative database data collectionThe qEEG-Pro normative database was constructed by using the resting-state EEG andquestionnaire data of clients that visited the Neurofeedback Institute Netherlands (NIN)between 2004 and 2013 in one of the 10 different Dutch cities the NIN is located( The EEG recording and questionnaire was done in order to guidesubsequent Neurofeedback treatment. All clients signed an informed consent form, whichstated that their anonymous EEG and questionnaire data may be used for researchpurposes. The questionnaire consisted of 292 questions (each rated from 0 to 8) that weredirectly based on the criteria of 46 DSM psychopathologies (CNC1020 ; The recordings were done using the 19-channel DeymedTruScantm EEG amplifier ( The electrode sites were positioned accordingto the international 10-20 system (see figure 3).Figure 3. Electrode positions and labels used for theresting-state EEG recordings of the qEEG-Prodatabase.Sampling frequencies of 128 Hz and 256 Hz were used (8% and 92% of the subjects,respectively). The EEG recording session consisted of an ‘Eyes Closed’ condition (EC) andan ‘Eyes Open’ condition (EO). In the both conditions, the clients sat in an upright position fora total of 10 minutes. The clients were instructed to keep their neck and facial musclesrelaxed and refrain from making an excess of eye movements or eye blinks in the EOcondition. A total of 1696 clients completed the questionnaire and the EC EEG recording. Atotal of 1364 clients completed the questionnaire and the EO EEG recording. 88(EC) and21(EO) clients showed epileptiform activity in their EEG and were excluded from the qEEGPro database. The duration of the de-artifacted EEG of 126 (EC) and 112 (EO) clients wasless than 1 minute and were therefore excluded from the qEEG-Pro database. So tosummarize, the EEGs of 1482 (EC) and 1231 clients were included in the qEEG-Pro. Clientsranged from 4 to 82 years of age. Figure 4 shows the age and gender distribution for boththe EC and the EO condition.Version 1.76

Figure 4. Age and gender distribution of the qEEG-Pro normative database.12.2 qEEG-Pro EEG data analysisAll metrics that are described in detail above were applied to the qEEG-Pro database. A totalof 150 subgroups (ages 1-75,5 years, 6 months resolution) were created by selecting 200subjects that had a minimum age difference with the age bin of interest. A regressionanalysis was performed for all (log-transformed) metrics, using the log-transformed data fromthe 47 psychopathologies categories in the questionnaire. The residuals of the regressionmodel represent the variance in the EEG data that cannot be explained by any of the 47psychopathologies. These residuals are then used to calculate the means and standarddeviations for all metrics.Version 1.77

Appendix 2. Practical guide for uploading raw EEGA3.1 Compatible devicesThe qEEG-Pro report service can process .edf files from the following EEG amplifiers:Deymed TruScanBrainmaster DiscoveryDSI24 / Freedom 24MindMedia NexusMitsarA3.2 Data export instructionsFollow the steps below to start using the qEEG-Pro report service.Step 1. Locate the .edf file containing your client’s EEG on your computer.For BrainMaster Discovery users: The .edf file is automatically generated by theBrainMaster software.For Deymed TruScan users: Generate an .edf file in TruScan Explorer by clicking on the‘export file’ button.An options dialog will pop up. Select EDF and use the same settings as depicted in theimage below.Version 1.78

For Mitsar users: Go to the main drop-down menu in EEGStudio and select ‘Export to’- ‘EDF ( ) file’ (see below).For MindMedia Nexus users: Go to ‘File’ - ‘Export Session Data’ in Polyman Viewer withthe ‘Output Format’ set to ‘EDF -------------------------------2. After you have logged into the user environment, click on the ‘Clients’ tab and fill out theform.3. Click on the ‘EEG’ tab and then on ‘Add EEG’.4. Select the appropriate client, fill out the form and upload the raw EEG.Version 1.79

The age of the client can easily be selected by using the calendar tool. Left click on the upperpanel in the calendar tool to switch from ‘days’ to ‘months’ and ‘years’ (see below).5. After the upload is complete, you can safely log out of the system by clicking on the‘Logout’ tab. The estimated processing time for QEEG-Pro reports is 60 minutes, after whichthe QEEG-Pro reports can be downloaded to your computer.A3.3 Client sensitive information and Data security- The qEEG-Pro report service assures that no client sensitive information that mayaccompany your uploaded EEG files will be accessible to third parties.- The raw and processed EEG files and the QEEG reports will be stored on the qEEG-Proreport service servers but the qEEG-Pro report service cannot be held responsible forsituations in which the raw data or the reports are no longer accessible for the user. The useris recommended to back up their EEG files and qEEG reports on a (hard)disk or backupserver/webservice.A3.4 Instructional Videos, Expert Coaching and SupportFor the qEEG-Pro instructional videos library, go o/If you need support for the use of the qEEG-Pro Report Service, got to:Version 1.710 also offer qEEG-Pro Expert Coaching if you want to discuss specific patients or whenyou want to go into more detail about specific qEEG-Pro analyses. Dr. Keizer is the creatorof the qEEG-Pro Report Service and is available for expert coaching on the following topics: recording qualityInterpretation of qEEG-Pro analysesProtocol recommendationSetting up a scientific neurofeedback experimentAnalyzing EEG data using MatlabIf you would like to make use of Expert Coaching, go rt-coaching/Version 1.711

ReferencesDelorme, A., & Makeig, S. (2004). EEGLAB: an open source toolbox for analysis ofsingle-trial EEG dynamics including independent component analysis. Journal ofNeuroscience Methods, 134(1), 9-21Manufactured by:BrainMaster Technologies, Inc.195 Willis Street, Suite 3Bedford, OH 44146United StatesPhone: [email protected] 1.712

BrainMaster Technologies, Inc. 195 Willis Street, Suite 3 Bedford, OH 44146 United States Phone: 440